ClouDx-i
  • Home
  • News
  • Events
  • Publications
  • Public Documents
  • Jobs
  • About us

Papers on neonatal sepsis and Inflammatory response

20/11/2013

0 Comments

 
Picture
Inflammatory response during sepsis is incompletely understood due to small sample sizes and variable timing of measurements following the onset of symptoms.   This paper from the James Hogg Research Centre and Pulmonary & Critical Care Medicine at Stanford University looks at cytokines and signalling molecules in an attempt to predict clinical outcomes in Sepsis.  

The research found a distinct pattern of cytokine levels measured early in the course of sepsis predicts disease outcome. Sub-populations of patients have differing clinical outcomes that can be predicted accurately from small numbers of cytokines. Design of clinical trials and interventions may benefit from consideration of cytokine levels.

Ref:  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0079207#ack


This paper from University of Würzburg looks at altered neonatal Toll-like receptor (TLR) function which is hypothesized to contribute to the heightened susceptibility to infection and perpetuated inflammation in term and preterm neonates, clinically evident in neonatal sepsis and increased rates of inflammatory disorders.  Current data indicates that basal TLR expression in term neonates equals adult expression patterns, while expression in preterm infants seems to increase, depending on gestational age. Regarding TLR signaling, some studies suggest TLR incompetence in neonates associated with impaired pro-inflammatory responses, others describe neonatal TLR function well developed and allude to its hyper-inflammation tendency. 

Ref:  http://www.expert-reviews.com/doi/abs/10.1586/1744666X.2013.857275

0 Comments

Accelerating in silico research with workflows: A lesson in Simplicity

19/11/2013

1 Comment

 
Picture
 nSilico LifeSciences, Ltd and the Department of Biological Sciences at Cork Institute of Technology recently published a paper in the Computers in Biology and Medicine journal where they describe the development of a sequence information management platform (Simplicity), a workflow-based bioinformatics management tool, which allows non-bioinformaticians to rapidly annotate large amounts of DNA and protein sequence data.

Simplicity is a bespoke bioinformatics management system that allows biologists to manage and analyse information generated from large scale ‘omic’ projects, facilitating quick transition from ‘project-to-publication’ or ‘lab-to-licence’. The authors engaged with over 120 professional researchers across the spectrum of biological sciences (using a qualitative analysis based approach involving both focus groups and online surveys) to develop a software framework that meets academic and industry demands. Simplicity has been developed as a cloud based Software as a Service (SaaS) solution, allowing for rapid deployment of extended features in response to increasing user needs.

The software is currently in development to meet the needs of Next Generation Sequencing projects (NGS) where detection of SNP's (single nucleotide polymorphism) and Indels (INsertion/DELetion) are of great interest to researchers investigating differences between members of a biological species.

ClouDx-I researchers contributed to the paper.

Reference: http://www.sciencedirect.com/science/article/pii/S001048251300262X

1 Comment

Cork centre publishes perinatal death audit

18/11/2013

0 Comments

 
Picture
An audit was published by the National Perinatal Epidemiology Centre based in Cork and is a first for the country.  The first national audit of stillbirths and the deaths of babies within four weeks of being born has been published.

It indicates that there were almost 500 perinatal deaths in Ireland during 2011, with stillbirths accounting for the majority of these.  

http://www.rte.ie/news/2013/1022/481903-perinatal-research/


0 Comments

    Archives

    March 2015
    February 2015
    November 2014
    August 2014
    June 2014
    May 2014
    April 2014
    March 2014
    February 2014
    December 2013
    November 2013
    October 2013
    August 2013
    February 2013

    Categories

    All
    Dna
    News
    Paper


    European Comission
     This project is partly funded by the European Commission

Powered by Create your own unique website with customizable templates.